For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only
COMPOSITION
Each 5 ml of WORNO suspension contains:
Albendazole 200 mg
Each chewable micronized tablet of WORNO contains:
Albendazole - 400mg
CATEGORY anthelmintics or anti-worm medication
MECHANISM OF ACTION
Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).
INDICATION AND DOSAGE
Echinococcosis
Adult: >60 kg: 400 mg bid for 28 days; <60 kg: 15 mg/kg daily in 2 divided doses. Max dose: 800 mg daily.
For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles.
For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between.
Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.
Neurocysticercosis
Adult: >60 kg: 400 mg bid; <60 kg: 15 mg/kg daily in 2 divided doses for 8-30 days.
Max Dosage: Adult <60 kg: 800 mg daily.
Ascariasis, enterobiasis, hookworm infections or trichuriasis
Adult: 400 mg as a single dose.
Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.
it is recommended that all household contacts of patients with enterobiasis ( pin worm ) receive treatment, especially when multiple or repeated symptomatic infections occur, since such contacts commonly also are infected
Strongyloidiasis
Adult: 400 mg once daily or bid for 3 consecutive days, repeated after 3 wk if necessary.
Giardiasis
Adult: 400 mg daily for 5 days.
Child: 400 mg daily for 5 days.
ADMINISTRATION
Should be taken with food.
OVERDOSAGE
Symptomatic and supportive measures are advised.
CONTRAINDICATIONS
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.
SPECIAL PRECAUTIONS
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
ADVERSE DRUG REACTIONS
GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth.
Potentially Fatal: Bone marrow depression.
DRUG INTERACTIONS
Cimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent.
PREGNANCY Category (US FDA)
Category C
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: ALBENDAZOLE,ANTHELMINTIC,WORNO
