For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only
IGON INJECTION
IGON - 250 / 500
Each vial contains -sterile ceftriaxone sodium USP
Eq. to ceftriaxone--- 250 mg / 500 mg
sterile water for injection I.P.--- 5 ml
IGON - 1000
Each vial contains -sterile ceftriaxone sodium USP
Eq. to ceftriaxone--- 1000 mg
sterile water for injection I.P.--- 10 ml
CATEGORY - antibiotic
3rd generation parenteral cephalosporinMODE OF ACTION
IGON inhibits the cell wall synthesis of bacteria by binding to target proteins and kills the bacteriaPHARMACOKINETICS
bioavailability 100 %t 1/2 6-9 hr
excretion 40- 50% through urine in adults and 70% in neonates.
INDICATIONS
1 life threatening infections2 typhoid fever
3 bacteraemia / septicaemia
4 bacterial meningitis
5 urinary tract infections
6 gonococcal infections
7 lower respiratory infections and pneumonia
8 acute bacterial otitis media
9 skin and soft tissue infections
10 bone and joint infections
11 prophylaxis of post operative infections
DOSAGE
adults- 1 - 2 g once daily , or twice dailyneonates / children - 50 -70 mg /kg IM/IV once in a day
MAX. DOSAGE
adult 4 gram /daypaediatrics 2 gram / day
RISK CATEGORIES
PREGNANCY -----------------category B ( Can be given 2nd trimester onwards )LACTATION ------------------can be given
PEDIATRICS ------------------safe in neonates
HEPATIC IMPAIRMENT ---no dose adjustment required
RENALIMPAIRMENT ------no dose adjustment required
CONTRA INDICATIONS
IGON is contraindicated in patients with known allegy to the cephalosporin class of antibiotics.ADVERSE EFFECTS
IGON can cause diarrohea , fever , pruritus , anaphylaxisSALIENT FEATURES
1 IGON has relatively longer half life as compared to other 3rd generation cephalosporins2 Stable against beta lactamase
3 Antibacterial activity of IGON starts immediately even after an IM dose.
4 Serum concentration after 24 hrs provides sufficient antibacterial activity against many organisms like S. pneumoniae , S . pyogenes , S . aureus , klebsiella sp. , H. influenzae , M. catarrhalis , E. coli , Proteus mirabilis
4 Highly potent against most of the gram +ve and -ve respiratory pathogenes.
5 Once daily dosing convenience
6 Anti bacterial activity of IGON against gram -ve is stronger that of oral cephalosporin.
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: ANTIBIOTIC,CEFTRIAXONE,IGON,INJECTABLES
