For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only
COMPOSITION
IGON-O 100
Each uncoated dispersible tablet contains:
cefpodoxime proxetil
eq. to Cefpodoxime 100 mg
IGON-O 200
Each film coated tablet contains:
cefpodoxime proxetil
eq. to Cefpodoxime 200 mg
IGON-O dry syrup
Each 5 ml of reconstituted suspension contains:
cefpodoxime proxetil
eq. to Cefpodoxime 50 mg
IGON-O drops
Each ml of reconstituted suspension contains:
cefpodoxime proxetil
eq.to Cefpodoxime 25 mg
CATEGORY antibiotics-3rd generation oral cephalosporin
INDICATIONS
1 Respiratory tract infections
2 Skin and soft tissue infections
3 Urinary tract infections
4 Sexually transmitted disease
5 Enteric fever
MODE OF ACTION
Bactriocidal - IGON - O kills bacteria by inhibiting cell wall synthesis by binding to target protein.
DOSAGE
Pharyngitis 100 mg BD x 5-10 days
Tonsillitis 100 mg BD x 5-10 days
Community Acquired Pneumonia (CAP) 200 mg BD x 14 days
Skin and Soft Tissue Infections 400 mg BD x 7-14 days
Uncomplicated UTI 100 mg BD x 7 days
Sexually Transmitted Diseases (STD)
Uncomplicated gonorrhea 200 mg single dose
Acute Bacterial Exacerbation of Chronic Bronchitis (AECB)
200 mg BD x 10 days
( ref: drugs facts and comparison.2006.60th edition,pg no.1569)
Pediatric dose
10 mg /kg/day q 12 hr
(ref: nelson textbook of pediatrics 17th ed.page 2487)
In typhoid fever
10-20 mg/kg/day
( ref: the indian journal of pediatrics 2004.vol 71 issue 5 pg.no 413-415)
cefpodoxime showed 86% efficacy in the treatment of typhoid fever in children
( ref: the indian j. of pediar,2004,vol 71,issue 5 pg 413-415)
cefpodoxime can be given to children and infants ages 15 days and older in a dose of 4 mg - 5 mg /kg every 12 hrs,for infections of respiratory tract ,urinary tract and skin and soft tissues.
(ref: martindale,35th ed.pg no 207)
CONTRINDICATIONS
Hypersensitivity to cefpodoxime.
SPECIAL PRECAUTIONS
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
ADVERSE DRUG REACTIONS
Anaphylactic shock; purpuric nephritis, skin rash, pruritus; diarrhoea, nausea, abdominal pain, vomiting.
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
DRUG INTERACTIONS
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.
Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.
SALIENT FEATURES
- USFDA approved in acute otitis media and acute sinusitis.
- Better healing rates than cefixime and coamoxyclav in painful otitis media.
(ref: pediatr infect dis j.1995april;14( 4 suppl): s 12-8
- Broadest spectrum among all oral beta-lactam antibiotics.
( infection.1984 sep-oct;22(5):370-5)
- Less chances ( 3.4% )of diarrhoea than cefixime ( 13% )
- Ten times higher potency than cefixime against s.pneumoniae
( int.j.antimicrobial agents, vol 25, issue 2, feb 2005,pg 120-129)
- More potent than cefaclor,cefixime against pneumococci.
- Cefpodoxime is the only third generation cephalosporin with activity against s. aureus.
- Can be given in pregnancy ( category B)
- Cefpodoxime showed 86% efficacy in the treatment of typhoid fever in children
( ref: the indian j. of pediar,2004,vol 71,issue 5 pg 413-415)
- Cefpodoxime is safe even in 15 days old child.
(ref: martindale,35th ed.pg no 207)
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: ANTIBIOTIC,CEFPODOXIME,IGON O
