COMPOSITION
Each film coated tablet of ORFY L-250 contains:
levofloxacin 250 mg
Each film coated tablet ORFY L-500 contains:
levofloxacin 500 mg
CATEGORY antibiotics- 3rd generation oral fluoroquinolone.
INDICATIONS / DOSAGE
Acute sinusitis 500 mg OD for 10-14 days.
Acute bacterial exacerbation of chronic bronchitis
500 mg OD for 7 days.
Community-acquired pneumonia 500 mg OD for 7-14 days.
Uncomplicatd skin infections 500 mg OD for 7-10 days.
Nosocomial pneumonia;Complicated skin infections
750 mg OD for 7-14 days.
Uncomplicated UTI 250 mg OD for 3 days.
Acute pyelonephritis;Complicated UTI
250 mg OD for 10 days.
Chronic bacterial prostatitis 500 mg OD for 28 days.
MDR - TB 750 mg od x 24 months
MODE OF ACTION
levofloxacin kills bacteria by inhibiting DNAgyrase and DNA topoisomerase 4 enzyme.
ADMINISTRATION
May be taken with or without food. (Ensure adequate fluid intake.)
ADVERSE DRUG REACTIONS
Nausea, diarrhoea, constipation, headache, insomnia
CONTRAINDICATIONS
hypersensitivity to levofloxacin,Child <18 yr.
PRECAUTIONS
Pregnancy ( CATEGORY C ) and lactation.
SALIENT FEATURES
Convenient od dosage schedule
It is a drug of choice in UTI - 99% boiavailability and >87% excreted in urine unchanged.
Levofloxacin 750 mg od for 5 days is as effective as ten days course of the therapy with ciprofloxacin 400 mg iv or ciprofloxacin 500 mg orally twice daily for the treatment of acute pyelonepheritis and complicated UTI
Shows higher bactericidal activity as compared to ofloxacin
( ref: j antimicrob agents chemother 1997,39,719-723)
offers MIC 90 values 50% lower than those observed with ofloxacin.
WARNING! Be sure to consult your doctor before taking any medication!
Posted in: ANTIBIOTIC,LEVOFLOXACIN,ORFY-L-500
