For the use of a Registered Medical Practitioner, a Hospital or a Laboratory only
COMPOSITION
Each film coated tablet of TGON-MR contains
Aceclofenac 100 mg
Paracetamol 325 mg
Chlorzoxazone 250 mg
CATEGORY analgesic and anti-inflammatory with muscle relaxant
Aceclofenac - novel NSAID;selective COX-2 inhibitor.
Paracetamol - analgesic and antipyretic
Chlorzoxazone - an efficient muscle relaxant
TGON-MR is a potent anti-inflammatory and analgesic with advantage of muscle relaxant property of chlorzoxazone.
MODE OF ACTION
Aceclofenac - aceclofenac when administered penetrates the inflammatory cells.aceclofenac suppresses the prostaglandin synthesis by COX-2 induction which results in anti-inflammatory action i.e. no inflammation and pain.
Paracetamol - paracetamol acts by blocking the synthesis of pro-inflammatory prostaglandins and also by blocking nociceptors which results in increasing pain threshold and hence no feeling of pain.
Chlorzoxazone - it acts at the level of the spinal cord and results in inhibiting the message transfer through motor neurons.thus gives relief from muscular pain
INDICATIONS
Painful muscle spasm associated with musculoskeletal conditions
Sprain
Strain
Cervical pain - neck pain
Shoulder pain
Lumbago low back pain
Dental pain
Primary dysmenorrhoea - painful menstrual cycle
Ankylosing spondylitis- spinal arthritis
ADMINISTRATION
Should be taken with food.
CONTRAINDICATIONS
Hypersensitivity, Moderate to severe renal or hepatic impairment, severe heart failure, Porphyria. Lactation ,pregnancy (third trimester).
SPECIAL PRECAUTIONS
GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; haemorrhagic disorders; hypertension; cardiac impairment.
Elderly. Caution when driving or operating machinery. Monitor renal and hepatic function and blood counts during long term treatment.
Persistently elevated hepatic enzyme levels may require drug withdrawal. Pregnancy, lactation.
ADVERSE DRUG REACTIONS
Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Aceclofenac: Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.
chlorzoxazone Drowsiness, dizziness, lightheadedness, headache, excitement, restlessness, GI disturbances, irritability, sensitivity reactions (skin rash). Jaundice, liver damage reported. Orange or reddish-purple urine.
DOSAGE 1 tab BD
SALIENT FEATURES
Aceclofenac - a novel NSAID with multiple mode of actions,rapid onset of action i.e.30 min. with 100% bioavailability It is ell tolerated with comparatively lower G.I. side effects than conventional NSAIDS
Paracetamol- safe and trusted analgesic
Chlorzoxazone - an efficient muscle relaxant
TGON-MR provides faster relief in pain
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: MUSCLE RELAXANT,PAIN KILLER,TGON - MR
