COMPOSITION
Each film coated tablet of APPICAL contains :
Calcium carbonate IP
eqv. to elemental calcium 500 mg
Magnesium hydroxide IP
eqv. to elemental magnesium 75 mg
Zinc sulphate monohydrate USP
eqv to elemental zinc 4 mg
Vitamin D3 IP 250 IU
CATEGORY calcium supplements
Calcium in the body is found stored in the bones and teeth, a small amount is also found in the bloodstream Calcium in the blood has many important roles to play: it transports nutrients across cell membranes; produces hormones and enzymes involved in digestion and metabolism; is involved in nerve cell communication; promotes blood clotting and woundhealing; and assists with muscle contractions.
Magnesium also plays an important role in maintaining the function of nerves and regulating muscle relaxation. A deficiency in magnesium is associated with the occurrence of muscle spasms, tremors and convulsion.Low magnesium levels have also been associated with psychiatric problems such as depression and schizophrenia
Vitamin D is a fat soluble vitamin that regulates calcium and magnesium metabolism in the body.
Vitamin D promotes intestinal absorption of calcium, mobilization of calcium from bone stores, and retention of calcium by the kidneys. It is therefore essential for the calcification of bones and teeth.
New research has also found Vitamin D inversely associated with the incidence of upper respiratory tract infections.
Zinc is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function , protein synthesis , wound healing , DNA synthesis , and cell division . it also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell .Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and eye and skin lesions . Weight loss, delayed healing of wounds, taste abnormalities, and mental lethargy can also occur
DOSAGE
1 tab of APPICAL BD
INDICATED BENEFITS OF APPICAL
1 Maintains strong bones and healthy teeth
2 Helps prevent osteoporosis to reduce the risk of fractures later in life
3 May help reduce high blood pressure
4 Plays a role in relieving symptoms of PMS
5 Supports colon health
7 Good for adolescents and post-menopausal women
8 Aids function of nerves and muscles, including regulation of normal heart rhythm
9 Maintains steady metabolism
10 Indicated in decreased levels of parathyroid hormone (acute and chronic)
11 Supplementation should be given for postmenopausal osteoporosis
12 helpful in rickets and osteomalacia (softening of the bones)
CONTRAINDICATIONS
APPICAL is contraindicated in patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia
SPECIAL PRECAUTIONS
Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment;
frequent monitoring of serum calcium and phosphorus is recommended.
DRUG INTERACTIONS
APPICAL may affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations.
ADVERSE DRUG REACTIONS
APPICAL can cause Constipation, flatulence, nausea, abdominal pain and diarrhoea. Pruritus, rash and urticaria.
STORAGE CONDITIONS
Oral: Store below 25°C. Store APPICAL at room temperature
WARNING!
Be sure to consult your doctor before taking any medication!
"The information containes herein is not intended to cover all possible uses,directions,precautions,warnings,drug interactions, allergic reactions,or adverse effects.if you have questions about the drugs you are taking, check with your doctor"
Posted in: APPICAL,CALCIUM SUPPLEMENT,VITAMIN D3,VITAMINS,ZINC SUPPLEMENT
